SUMMARY: N-Acetylcysteine (NAC) may have benefit in treating tobacco use disorder (TUD) by reducing cravings and smoking reward. In a 12-week double blind randomized
controlled trial of NAC at 3 g/day versus placebo, NAC treatment significantly reduced
the daily number of cigarettes used (-10.9) and CO (exhaled) (-10.4 ppm). 47.1%
of those treated with NAC were able to quit smoking. NAC treatment significantly
reduced the Hamilton Depression Rating Scalescore in patients with tobacco use disorder.
“N-acetylcysteine for therapy-resistant tobacco use disorder: a pilot study.” Redox Rep. 2015 Sep;20(5):215-22. 51328Dr. Michael Maies, IMPACT Strategic Research Centre, School of Medicine Deakin University, PO Box 281, Geelong 3220, VIC, Australia firstname.lastname@example.org.
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