Research in Nutrition, Prevention, and Integrative Medicine: August 2, 2025

Nutrition, Prevention and Integrative Medicine…

AGING - DIET - BEANS - LEGUMES -5 Delicious Ways to Eat a Cup of Beans Each Day By Tim Cebula, Blue Zones News Letter, July 2025.
1) Savory Roasted Chickpeas
2) Sardinian Pasta Fagioli
3) One-Hour, Crowd-Feeding Chili
4) Red Beans And Rice
5) Lentil Gnocchi
6) Ikarian Longevity Stew With Black Eyed Peas
7) Okinawan Rice and Bean Sprouts
8) Black Bean Breakfast Burritos
9) Panchita’s Gallo Pinto
10)Miso Soup with Vegetables
11) Black Bean Chocolate Chunk Brownies
12) Bush Beans - Blue Zones

AGING - DIET - CARBOHYDRATES - WOMEN - The Truth About Carbs For Women’s Health, According To Science, By Ava Durgin, , MindBodyGreen, July 28, 2025.
1) Dietary Carbohydrate Intake, Carbohydrate Quality, and Healthy Aging in Women.

AGING - PRESCHOOL - INTERGENERATIONAL PROGRAMS - What Happens When You Integrate a Preschool into a Long-Term Care Facility? Joy and Purpose for All. By Aislinn Kotifani, Blue Zones Newsletter, 2025.
1) Multigenerational Living Is the New Rapidly Growing Trend.
2) Intergenerational programs: What can school-age children and older people expect from them? A systematic review.
3) MAKING THE CASE FOR INTERGENERATIONAL PROGRAMS.
4) Intergenerational Day Centers: A New Wave in Adult and Child.

ALZHEIMER’S DISEASE - EGG - Association of Egg Intake With Alzheimer’s Dementia Risk in Older Adults: The Rush Memory and Aging Project. (“…These findings suggest that frequent egg consumption is associated with a lower risk of Alzheimer’s dementia and AD pathology, and the association with Alzheimer’s dementia is partially mediated through dietary choline…”). Kirk’s Comment: Eggs are one of the more frequent allergens/food intolerances while on paper good nutritionally. If you eat them daily or 3-4 times per week take two weeks off and see if any annoying symptoms go away or come back upon reintroduction. Eggs also have been associated with Type 2 diabetes. Make sure you are trim and have an hemoglobin A1C 5.6 or less if you are an egg eater.

BLOOD PRESSURE - BEET JUICE - Ageing modifies the oral microbiome, nitric oxide bioavailability and vascular responses to dietary nitrate supplementation. “…Greater blood pressure benefits from supplemental dietary nitrate in older compared to younger people are mediated primarily by the suppression of potentially harmful oral bacteria, that have been associated with ammonia production…”

BRAIN VOLUME - MAGNESIUM - Dietary magnesium intake is related to larger brain volumes and lowerwhite matter lesions with notable sex differences.

CARDIOVASCULAR DISEASE - COCOA FLAVONOL - Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.

CARDIOVASCULAR EVENT - Systematic Review Finds Devastating Cardiopulmonary Adverse Events after COVID-19 Vaccination. Thousands of Papers Identified Heart and Lung Damage, Biased AI Falsely Claims "Rare and Mild". Peter A. McCullough, MD, MPH, Focal Point/Courageous Discourse, Jul 29, 2025.

COGNITIVE FUNCTION - CARDIOVASCULAR DISEASE - Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial.

COGNITION - SLEEP - This One Sleep Habit Might Matter More Than Hours Slept For Cognitive Health, By Ava Durgin, MindBodyGreen, July 25, 2025.
1)Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer’s disease-vulnerable regions.
2) β-Amyloid accumulation in the human brain after one night of sleep deprivation.
3) The Dynamic Relationship between the Glymphatic System, Aging, Memory, and Sleep.
4) The effect of caffeine on subsequent sleep: A systematic review and meta-analysis.
5)Exercise improves the quality of slow-wave sleep by increasing slow-wave stability.
6) The effect of alcohol on subsequent sleep in healthy adults: A systematic review and meta-analysis.

COLORECTAL CANCER - VITAMIN D - Vitamin D’s Potential Role in Colorectal Cancer Prevention, Immune Health.

COLORECTAL CANCER - VITAMIN D - Vitamin D and Colorectal Cancer Prevention: Immunological. “…Maintaining optimal vitamin D levels and adequate dietary intake is crucial in preventing CRC and improving patient prognosis…”

DEMENTIA - IVERMECTIN Testimonial in Dementia - 92 year old mother in Japan has incredible response to low dose Ivermectin in her last months. Dr. William Makis MD, Covid Intel, Aug 01, 2025.

DEPRESSION - MAGNESIUM - Magnesium Depletion Linked to Depression and How to Replenish It Effectively. Personalized nutrition strategies offer new hope for low magnesium and mood disorders. By Zena le Roux, EPOCH Times, 7/28/2025.
1) Magnesium depletion score and depression: a positive correlation among US adults.
2) Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose–Response Meta-analysis of Epidemiologic Studies.

DIABETES RISK - SUGAR - 'Drinking your sugar is more problematic for health than eating it'
1) Dietary Sugar Intake and Incident Type 2 Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.

DIABETES RISK - VITAMIN D - Vitamin D Helps Balance Blood Sugar & Reduce Type 2 Diabetes Risk. By Morgan Chamberlain, MindBodyGreen, July 21, 2025.
1) Prevalence of Vitamin D Deficiency among Patients with Type 2 Diabetes in Qingdao, China.
2) Vitamin D and type 2 diabetes. (Dr. Paul Lips, Department of Internal Medicine, Endocrine Section, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. p.lips@vumc.nl )

ENVIRONMENT - GREENHOUSE GASES - CARBON DIOXIDE -Physics Demonstrates That Increasing Greenhouse Gases Cannot Cause Dangerous Warming, Extreme Weather Or Any Harm. More Carbon Dioxide Will Create More Food. Driving Greenhouse Gas Emissions to Net Zero and Eliminating Fossil Fuels Will Be Disastrous for People Worldwide. SUMMARY FULL PAPER by
1) Richard Lindzen, PhD, Professor of Earth, Atmospheric, and Planetary Sciences, Emeritus, Massachusetts Institute of Technology
2) William Happer, PhD, Professor of Physics, Emeritus, Princeton University

FIBROMYALGIA - DIET - SUPPLEMENTS - STRESS - SLEEP - EXERCISE - ALTERNATIVE THERAPIES - Fibromyalgia: A Chronic Condition With Widespread Pain—Natural Ways to Relieve It. Fibromyalgia affects how the body processes pain, leading to a range of symptoms. By Mercura Wang, EPOCH Times, July 22, 2025.

INFECTIOUS DISEASE - POST COVID PANDEMIC - Pandemic Aftermath: Why Infectious Diseases Are Surging—And How I’d Treat Myself If I Fell ILL. Here, I do a deep dive into the"mysterious" rise of infectious diseases worldwide—and my straightforward, practical approach to treating infectious illnesses if they were to strike me or my family. Pierre Kory, MD, MPA, Pierre Kory’s Medical Musings Jul 28, 2025.

LIVER DISEASE - CANCER - Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Liver Cancer and Chronic Liver Disease Mortality. “…Findings: In 98 786 postmenopausal women followed up for a median of 20.9 years, compared with consuming 3 servings or less of sugar-sweetened beverages per month, women consuming 1 or more servings per day had significantly higher rates of liver cancer (18.0 vs 10.3 per 100 000 person-years; adjusted hazard ratio [HR], 1.85) and chronic liver disease mortality (17.7 vs 7.1 per 100 000 person-years; adjusted HR, 1.68)…” (Author: Xuehong Zhang, MBBS, ScD, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Ave, Room 453, Boston, MA 02115 (xuehong.zhang@channing.harvard.edu).

MITOCHONDRIAL FUNCTION - VISION - SUNLIGHT - NEW STUDY: Sunlight Penetrates the Human Body, Improving Mitochondrial Function and Vision. Just 15 minutes of fully clothed infrared sunlight exposure triggered systemic effects and measurable improvements in vision — even with eyes completely covered. Nicolas Hulscher, MPH, Focal Points (Courageous Discourse), Jul 14, 2025.
1) Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision.

MITOCHONDRIAL DYSFUNCTION - SSRIs - SSRIs Can Cause Severe Mitochondrial Dysfunction. Installment eight in our series on understanding the truth about SSRIs. Chris Masterjohn, PhD, Harnessing the Power of Nutrients, Jul 29, 2025.

STROKE - HEMORRHAGIC - mRNA Injury Stories - 17 year old VOICE Star Karen Silva dies of hemorrhagic stroke. Dr. William Makis MD, Covid Intel, Aug 01, 2025.

SUDDEN DEATH - UNEXPLAINED - DOCTOR - mRNA Injury Stories - 30 year old Dr.Meliah Blair (Veterinarian) of Newport KY, died unexpectedly at her home on May 11, 2025. Dr. William Makis MD, Covid Intel, Jul 15, 2025.

THYROID FUNCTION - NUTRIENTS - IODINE- SELENIUM- IRON- ZINC- COPPER- MAGNESIUM - VITAMIN A - VITAMIN B12
1) The Role of Nutrition on Thyroid Function

TOXICITY - GLYPHOSATE - CHINA - Why Are We Paying China to Poison Us? And why did Congress just make it harder to fight back? Mollie Engelhart, EPOCH Times, 7/26/2025.

VACCINATION - EFFICACY - AMERICAN ACADEMY OF PEDIATRICS - American Academy of Pediatrics tacitly admits that vaccines don't work! If vaccines worked, vaccinated kids would have NOTHING to fear from unvaccinated kids. So why do we need to protect them? Steve Kirsch, Steve Kirsch's newsletter,
Jul 28, 2025.

Cancer…

BLADDER CANCER - COVID VACCINE - BLOOD CLOTS - After COVID-19 Vaccine Blood Clots, Deion Sanders Hit with Turbo Cancer. Unusual Aggressive Bladder Cancer Reported During Pandemic in Literature. Peter A. McCullough, MD, MPH, Focal Points/Courageous Discourse, Jul 31, 2025.

BLADDER CANCER - COVID-19 VACCINATION - Vaccination and Bladder Cancer Deion Sanders Vaccine Turbo Cancer Brings Issue to Light. Peter A. McCullough, MD, MPH, Aug 02, 2025.

BLADDER CANCER - IVERMECTIN - FENBENDAZOLE - High-Grade Non-Invasive Bladder Cancer, age 69, Male. Surgery, Ivermectin and Fenbendazole. Ben Fen, Jul 27, 2025.
1) Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients.

CANCER RISK - EXERCISE - This Simple Well-Researched Habit Cuts Cancer Death Risk By Nearly 50%. By Ava Durgin, MindBodyGreen, March 10, 2025. “…Could just 60 minutes of moderate exercise per week significantly improve cancer outcomes? According to a study published in the British Journal of Sports Medicine, the answer is a resounding yes?…”
1) Association between recorded physical activity and cancer progression or mortality in individuals diagnosed with cancer in South Africa.

PANCREATIC CANCER - IVERMECTIN and FENBENDAZOLE - 69 year old New York man with Stage 4 Pancreatic Cancer and CA19-9 14934 reports after 2 months. Dr. William Makis MD, Covid Intel, Jul 31, 2025.

PROSTATE CANCER - FENBENDAZOLE - Case Report: Metastatic Prostate Cancer, Liver and Lymph Node Metastases, age 74. Metastatic Stage IV Prostate Cancer Squashed with Fenbendazole. Ben Fen, Jul 29, 2025.

Covid Syndrome…

COVID VACCINATION - BOOSTER - IMMUNE SYSTEM - INFLAMMATION - COAGULATION - mRNA Boosters Trigger Dangerous Immune & Blood Abnormalities Within 48 Hours in Healthy Young Adults. Even without symptoms, mRNA boosters trigger immune suppression, systemic inflammation, and coagulation abnormalities. Nicolas Hulscher, MPH, Focal Point, Courageous Discourse, Jul 28, 2025.
1) Immune and hematologicak responses to the third dose of an mRNA COVID-19 vaccine: a six-month longitudinal study. “…Conclusions: A booster dose with an mRNA vaccine at the recommended time causes the anti-SARS-CoV-2 IgG and IgA levels to increase rapidly and for at least six months. The increase in inflammatory cytokines and changes in the coagulation profile are consistent with the vaccine’s normal immune induction mechanism. Mild AEFIs (adverse events following immunization) were reported in a minority of vaccine recipients. The consistent subclinical changes in inflammatory and coagulation markers suggest that these pathways may be involved in the pathogenesis of severe ARFIs reported with mRNA vaccines…”

COVID VACCINATION - GENETIC DISRUPTION - CANCER- CHRONIC DISEASE - BREAKING STUDY: mRNA Injections Induce Severe, Long-Lasting Genetic Disruption Linked to Cancer and Chronic Disease. Landmark study reveals COVID-19 “vaccines” severely disrupt the expression of thousands of genes—triggering mitochondrial failure, immune reprogramming, and oncogenic activation. Nicolas Hulscher, MPH, Focal Points/Courageous Discourse, Jul 25, 2025.
1) Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination. “…Conclusions: The observed transcriptomic profiles indicate persistent cellular stress responses, mitochondrial dysfunction, and immune dysregulation following exposure to mRNA vaccines, potentially in susceptible individuals. Shared and distinct molecular signatures in both cohorts demonstrate underlying mechanisms contributing to post-vaccine symptomatology and complications, including oncogenesis and or progression of malignant disease. These findings underscore the need for a deeper investigation into the long-term safety of mRNA vaccines and host response variability…”

COVID VACCINATION - HAIR LOSS - COVID-19 Vaccination — Not Infection — Increases Risk of Multiple Hair Loss Disorders. Massive study of 5.7 million Koreans finds COVID-19 vaccination significantly increases the risk of complete hair loss, patchy autoimmune hair loss, and excessive shedding. Nicolas Hulscher, MPH, Focal Points/Courageous Discourse, Jul 31, 2025.
1) New Onset of Hair Loss Disorders During the Coronavirus Disease 2019 Pandemic: A Korean Nationwide Population-Based Study. “…Conclusion: COVID-19 vaccination was positively correlated with hair loss disorders but not COVID-19 infection…”

COVID VACCINATION - MYOCARDITIS - MRI - Cardiac MRI One Year after COVID-19 Vaccination Valuable in Detecting Heart Damage. Sustained Myocarditis Concerning in Young Persons. Peter A. McCullough, MD, MPH, Focal Points/Courageous Discourse, Jul 27, 2025.
1) Resolution of Refractory COVID-19 Vaccine-Induced Myopericarditis with Adjunctive Rapamycin.
2) Improved diagnosis of COVID-19 vaccine-associated myocarditis with cardiac scarring identified by cardiac magnetic resonance imaging.

COVID VACCINATION -MYOCARDITIS - CARDIAC MRI - Improved diagnosis of COVID-19 vaccine-associated myocarditis with cardiac scarring identified by cardiac magnetic resonance imaging. (Professor Andrew J Taylor, Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia / Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia. andrew.taylor2@mh.org.au “…Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) occurred in one-third of patients with COVID-19 vaccine-associated myocarditis (C-VAM). Without CMR at the time of diagnosis, almost one-third of patients are misclassified as probable rather than definite myocarditis, indicating a diagnostic strategy using echocardiography alone is insufficient…”

COVID VACCINATION - SPIKE PROTEIN - NATTOKINASE - Spanish "Vaxtherapy" Positions Nattokinase First Line. Handling Spike Protein as Core Culprit is Primary Goal in Treating Long-Vax Syndromes. Peter A. McCullough, MD, MPH, Focal Points (Courageous Discourse), Jul 30, 2025.
1) Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects.

COVID VACCINATION - IMMUNE FUNCTION - INFLAMMATION- COAGULATION - mRNA Boosters Trigger Dangerous Immune & Blood Abnormalities Within 48 Hours in Healthy Young Adults. Even without symptoms, mRNA boosters trigger immune suppression, systemic inflammation, and coagulation abnormalities. Nicolas Hulscher, MPH, Focal Points, Courageous Discourse, Jul 28, 2025.
1) Immune and hematologicak responses to the third dose of an mRNA COVID-19 vaccine: a six-month longitudinal study.

POST COVID SYNDROME - BRAIN FOG - COGNITION - This SARS-spike thing they made ruins brains. A new study demonstrates hypometabolism (reduced glucose uptake) in specific areas of the human brain - think reason for brain fog. Jessica Rose, Unacceptable Jessica, Jul 15, 2025.
1) Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing. “…The results showed significant hypometabolism in the bilateral frontal, temporal, and parietal lobes, as well as in the left occipital lobe, along with predominantly frontal EEG slowing in post-COVID-19 patients compared to healthy controls…The observed PET hypometabolism and EEG slowing patterns in anterior brain regions, may help to elucidate the pathophysiological mechanisms underlying cognitive decline in post-COVID-19 patients…”

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Colon Cancer and Vitamin D, Mechanisms in Prevention and Treatment an Interview with Professors János Tamás Varga, MD and Mónika Fekete

Watch Kirk Hamilton PAC’s Video Summary of This Interview Here

Professor János Tamás Varga, MD
Department of Pulmonology, Semmelweis University
1083 Budapest, Hungary
varga.janos.tamas@semmelweis.hu

Mónika Fekete, MD
Institute of Preventive Medicine and Public Health
Faculty of Medicine, Semmelweis University
1089 Budapest, Hungary
fekete.monika@semmelweis.hu

“Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications,”
Nutrients. 2025 Apr 15;17(8):1351 (7/2025)

Kirk Hamilton: Can you please share with me your educational background and current position?

Dr. Mónika Fekete and Prof. János Tamás Varga: The authors of the study are affiliated with various faculties and research institutes of Semmelweis University, primarily working in preventive medicine, nutrition science, immunology, pulmonology, and cardiovascular medicine. Several authors hold medical degrees (MD) and PhDs, and currently serve as educators, researchers, or clinicians within different departments of Semmelweis University (e.g., Department of Preventive Medicine and Public Health, Heart and Vascular Clinic, Department of Rheumatology and Clinical Immunology, Department of Pulmonology). We also collaborate with the HUN-REN Energy Science Research Centre. The corresponding author of the article is Prof. János Varga, Professor at the Department of Pulmonology, Semmelweis University.

KH: What got you interested in studying the role of vitamin D in colorectal cancer prevention and treatment?

MF & JTV: Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related mortality worldwide. Therefore, research into preventive strategies is of high importance for public health and preventive medicine. The role of vitamin D has gained increasing attention not only for bone metabolism but also for its immunomodulatory and anti-inflammatory effects over the last decade.

Our research group was motivated by the observed epidemiological and clinical associations between vitamin D deficiency and CRC incidence. However, many underlying mechanisms remain unclear. We were particularly interested in exploring the immunological and inflammatory pathways involved, as they play key roles in carcinogenesis and could serve as targets for preventive strategies.

Furthermore, nutritional and lifestyle aspects of vitamin D — such as supplementation optimization and addressing population-wide deficiencies — are especially relevant for public health practice.

KH: What is the mechanism of how vitamin D adequacy may prevent colorectal cancer?

MF & JTV: Vitamin D, especially its active form calcitriol (1,25(OH)₂D₃), regulates multiple cellular processes critical in cancer prevention:

• Cell differentiation and proliferation inhibition: Activation of the vitamin D receptor (VDR) promotes normal cell differentiation and inhibits excessive cell division, which is crucial in colorectal epithelial cells where dysregulated proliferation can lead to cancer.

• Promotion of apoptosis: Calcitriol induces programmed cell death in damaged or transformed cells, eliminating potentially cancerous cells.

• Modulation of inflammatory pathways: Vitamin D suppresses pro-inflammatory cytokines (e.g., IL-6, TNF-α) while promoting anti-inflammatory mediators (e.g., IL-10), which is important given the link between chronic inflammation (such as ulcerative colitis) and CRC risk.

• Immunomodulation: Vitamin D balances innate and adaptive immunity, enhancing tumor-fighting cytotoxic T cells (CD8⁺) and reducing pro-tumor immune populations (e.g., Th17 cells).

• Effects on the microbiome: Vitamin D influences gut microbiota composition, which is linked to CRC development by maintaining intestinal barrier function and immune homeostasis.

In summary, vitamin D acts as an active biological regulator through multiple cellular and immunological pathways, contributing to colorectal cancer prevention.

KH: What is the mechanism of how vitamin D may be beneficial as an adjunctive treatment of colon cancer?

MF & JTV: The active form of vitamin D supports CRC therapy through:

• Antiproliferative effects by activating cell cycle inhibitors (p21, p27) that block tumor cell division.

• Induction of apoptosis via activation of BAX/BAK pathways.

• Inhibition of Wnt/β-catenin signaling, crucial in tumor development, and enhancement of E-cadherin and DKK-1 expression.

• Immunomodulation and reduction of inflammation, including suppression of IL-6 and IL-8.

• Antiangiogenic effects by decreasing HIF-1α and VEGF levels, inhibiting new blood vessel formation.

• Potential improvement of chemotherapy response and reduction of recurrence risk, particularly with optimal serum vitamin D and micronutrient levels (e.g., magnesium).

Thus, vitamin D has complex cellular and immune effects that make it a promising adjuvant in personalized combined CRC treatment.

KH: What role does vitamin D adequacy play in the prevention of recurrence of colorectal cancer?

MF & JTV: Increasing evidence suggests adequate vitamin D levels are important not only in preventing CRC onset but also in reducing recurrence and progression. Calcitriol’s immunomodulatory, anti-inflammatory, cell cycle inhibitory, and pro-apoptotic effects may suppress residual tumor cells and prolong cancer-free survival.
Several clinical studies support this:

• A meta-analysis by Lopez-Caleya et al. (2022) showed each 100 IU/day increase in vitamin D intake reduced CRC risk by 4%, independent of sex or region.

• Another meta-analysis found daily supplementation of 500–2000 IU vitamin D lowered CRC incidence (OR = 0.87) and improved long-term survival (HR = 0.91).

• The SUNSHINE trial demonstrated that high-dose (4000 IU) vitamin D3 alongside standard chemotherapy significantly prolonged progression-free survival in metastatic CRC (13 vs. 11 months).

• The COLON study indicated that serum 25(OH)D levels ≥ 50 nmol/L combined with higher magnesium intake significantly reduced CRC mortality (HR = 0.53).

• Postoperative supplementation studies observed better survival among patients with baseline 25(OH)D levels of 20–40 ng/ml.

• The VITAL trial subgroup analysis suggested vitamin D supplementation had more protective effects in patients with normal BMI than in overweight individuals.

Although not all studies showed significant differences, overall data suggest vitamin D supplementation—especially achieving optimal serum levels—may reduce recurrence risk and improve survival, influenced by individual factors like BMI, magnesium intake, and baseline vitamin D status.

KH: What is a “preventive” blood level of vitamin D3?

MF & JTV: The preventive blood level refers to the optimal serum 25-hydroxyvitamin D concentration associated with reduced risk of CRC development and recurrence. Current literature generally accepts a minimum level of 30 ng/ml (75 nmol/L), above which protective effects increase.

Some studies suggest levels of 36–40 ng/ml (90–100 nmol/L) may offer even stronger protection. Levels below 30 ng/ml indicate insufficiency or deficiency, associated with higher cancer and chronic disease risk.

It is important to avoid excessively high levels (>100 ng/ml or 250 nmol/L), which pose health risks such as hypercalcemia.
In summary:

• Minimum recommended: ≥ 30 ng/ml (75 nmol/L)

• Optimal/preventive range: 36–40 ng/ml (90–100 nmol/L)

• Potentially harmful level: > 100 ng/ml (250 nmol/L)

Individual needs and health status should guide supplementation, with medical supervision and regular monitoring.

KH: There is debate about the optimal serum level of vitamin D for cancer prevention, treatment and recurrence prevention. You leave a wide gap from ”Optimal” 36-40 ng/ml and ”Potentially harmful” > 100 ng/ml of 40-100 ng/ml? As a health practitioner who has done 1000s of vitamin D levels on patients I have never seen side effects under 100 ng/ml (unless they have parathyroid or kidney disease) and I see people taking 5000 IU routinely of vitamin D3 getting into the 30-50 ng/ml range. Personally for general health reasons and as someone who has had colon cancer I try and keep my vitamin D levels between 50-75 ng/ml. That takes about 10,000 IU per day 5-7 days per week. A 2000 IU/d dose for an adult seems to be low in my clinical experience to get levels even to 30 ng/ml? To me toxic side effects between 30-100 ng/ml are not an issue. What needs to be done is doses studied between 5000-10,000 IU per day to a get level between 50-100 ng/ml to see if there really is clinical benefit in colon cancer prevention, treatment and cancer recurrence.

1. Vitamin D Page 73 https://imahealth.org/wp-content/uploads/2023/06/Cancer-Care-FLCCC-Dr-Paul-Marik-v2.pdf

2. Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines

You may have already addressed this in your answers above but do you have any additional comments on higher doses of vitamin D for prevention, adjunctive cancer treatment and prevention of cancer recurrence?

MF & JTV: Thank you for the thoughtful comments and clinical insights. We agree that the currently accepted optimal serum levels of vitamin D are indeed debated, particularly in oncology. While most population guidelines (including those from WHO and national authorities) define 30–50 ng/mL as a safe and physiologically sufficient range, some clinical observations — especially in cancer patients or those at high risk — suggest that higher levels (e.g., 50–75 ng/mL) might be beneficial.

However, it is important to note that vitamin D is a fat-soluble vitamin that accumulates in the body over time. Therefore, from a public health and safety standpoint, most national and international recommendations define 4000 IU/day as the tolerable upper intake level for healthy adults. Exceeding this level chronically may increase the risk of adverse events (e.g., nephrocalcinosis or hypercalcemia), especially in individuals with comorbidities or genetic susceptibilities.

In the SUNSHINE clinical trial — one of the most relevant interventional studies in metastatic colorectal cancer — patients received a bolus dose of 8000 IU/day only for the first 2 weeks, followed by 4000 IU/day as maintenance, confirming that even in oncology settings, long-term very high doses are typically avoided. PubMed link: https://pubmed.ncbi.nlm.nih.gov/30964527/

We fully acknowledge your clinical experience and agree that doses between 5000–10,000 IU/day may be necessary in certain cases (e.g., high BMI, limited sunlight exposure) to achieve higher serum levels. However, the long-term safety of sustained serum levels above 75–100 ng/mL still requires rigorous, randomized controlled trials, particularly in oncology.

Please note that we are not clinical oncologists, and in our article we approached the topic of vitamin D supplementation from a public health and preventive medicine perspective, not as a cancer treatment protocol. The SUNSHINE trial itself used only a short-term loading dose of 8000 IU/day followed by a maintenance dose of 4000 IU/day, which aligns with the globally recognized safe upper limit.

KH: What is a good blood level of vitamin D to achieve while someone is being treated for colon cancer?

MF & JTV: For CRC patients undergoing treatment, maintaining an optimal 25(OH)D level between 30–50 ng/ml (75–125 nmol/L) is advised. This range is associated with improved survival, reduced recurrence risk, and favorable effects on immune function and inflammation.
Evidence includes:

• Epidemiological data linking serum 25(OH)D above 30 ng/ml to better prognosis and lower recurrence.

• Hormonal effects of vitamin D that support anti-cancer mechanisms and enhance treatment efficacy.

• Clinical practice recommends individualized supplementation with regular blood level monitoring, considering factors such as body weight, ethnicity, and ongoing therapies.

• Avoiding toxic levels (>100 ng/ml) is crucial to prevent hypercalcemia.
  Monitoring and maintaining appropriate vitamin D status is part of comprehensive cancer care to improve quality of life and outcomes.

KH: Can you tell us about your study and the basic results?

MF & JTV: Our study, titled “Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications,” aimed to provide a comprehensive overview of vitamin D’s role in CRC prevention, focusing on immunological mechanisms, inflammatory pathways, and nutritional aspects.
We performed a literature review analyzing vitamin D’s various effects on CRC risk reduction. Key highlights include:

• The active form, 1,25-dihydroxyvitamin D3, regulates tumor cell proliferation, promotes differentiation, and induces apoptosis, thereby inhibiting tumor growth.

• Vitamin D modulates inflammatory signaling pathways (e.g., NF-κB, IL-6, TNF-α) critical in CRC pathogenesis.

• Maintaining adequate vitamin D levels through sunlight exposure, diet, and supplementation is important for CRC prevention.

• Epidemiological and clinical data collectively suggest that optimal 25(OH)D levels can reduce CRC incidence and improve survival.

• We emphasize regular monitoring of vitamin D status, especially in high-risk populations.

Overall, our study supports that vitamin D plays a key role beyond bone health, acting through immune and inflammatory regulation to contribute to primary CRC prevention.

KH: Is there an advantage of vitamin D levels attained by being in the sun versus by vitamin D taken by mouth? Said differently, is there something from sun exposure that may additionally be beneficial for the prevention or treatment of colon cancer?

MF & JTV: Vitamin D levels can be raised both through skin synthesis triggered by sunlight exposure (UV-B radiation) and by oral vitamin D supplementation. However, vitamin D production via sunlight may have certain advantages. The synthesis of vitamin D3 in the skin is regulated by natural feedback mechanisms that limit excessive vitamin D formation, thereby reducing the risk of vitamin D toxicity. This regulation aligns with kidney-based control processes and represents the skin’s natural protective mechanism.

Moreover, UV radiation itself exerts multiple beneficial biological effects that may contribute to colorectal cancer prevention and treatment. Some studies have shown that sun exposure has positive immunomodulatory effects and promotes anti-inflammatory processes, which play important roles in slowing cancer progression. Vitamin D additionally induces apoptosis in certain cancer cell lines, including colorectal cancer cells, making the maintenance of adequate vitamin D levels crucial.

At the same time, sun exposure must be kept within safe limits to avoid the risk of skin cancer caused by excessive UV radiation. Proper photoprotection and avoiding sunburn maximize the benefits of sunlight-driven vitamin D synthesis. When UV exposure is limited—due to season, latitude, or other factors—oral vitamin D supplementation remains an effective and safe alternative.

In summary, vitamin D derived from sun exposure is advantageous not only due to its natural regulatory mechanisms but also because of the additional immune- and inflammation-modulating effects of UV radiation, which may contribute to colorectal cancer prevention and treatment. Achieving optimal effects requires both safe sun exposure practices and medically supervised vitamin D supplementation.

KH: How important is vitamin D as a single nutrient/hormone in the prevention, treatment, and prevention of recurrence of colon cancer?

MF & JTV: Vitamin D plays a significant role as a single nutrient and hormone in the prevention, treatment, and prevention of recurrence of colorectal cancer. Numerous epidemiological and clinical studies have demonstrated that maintaining adequate serum 25(OH)D levels—generally above 30 ng/mL (75 nmol/L)—is associated with a reduced risk of colorectal cancer and improved survival outcomes in patients.

Mechanistically, the active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3), exerts multiple cellular effects that directly influence tumor progression. It promotes apoptosis of cancer cells, inhibits proliferation, reduces inflammation, and supports the effective functioning of the immune system. These actions are key not only in preventing tumor development but also in treating existing tumors and decreasing the risk of disease recurrence.

However, it is important to note that colorectal cancer is a complex disease influenced by numerous genetic, environmental, and lifestyle factors. Therefore, vitamin D should not be regarded as a standalone “miracle cure” but rather as part of a comprehensive preventive and therapeutic strategy that includes appropriate lifestyle, nutrition, and medical treatment.

In summary, vitamin D is a key nutrient and hormone in colorectal cancer prevention, treatment, and recurrence prevention, but its effectiveness is best realized within a multidisciplinary approach.

KH: Do you have any further comments on this interesting topic?

MF & JTV: Raising serum 25-hydroxyvitamin D levels above 30 ng/mL (75 nmol/L) can significantly contribute—based on many epidemiological and clinical studies—to reducing the risk of chronic diseases, including colorectal cancer. Higher vitamin D levels have also been associated with decreased mortality from conditions such as cardiovascular disease, stroke, diabetes, and respiratory infections.

Currently, vitamin D supplementation is the most effective and controllable method to achieve and maintain the desired 25(OH)D concentration, especially when sunlight-driven synthesis is limited. The optimal minimal daily dose for healthy adults with normal body weight is approximately 2000 IU (50 µg), which allows reaching serum levels of 30–40 ng/mL with minimal safety risks. Supplementation can be administered daily, weekly (e.g., 15,000 IU), or monthly (e.g., 60,000 IU), with weekly or monthly dosing often improving patient compliance.

Loading doses (“bolus”) given in the first one or two weeks can rapidly raise vitamin D levels, while lower doses maintain a stable concentration over time. This approach enables personalized supplementation, considering the patient’s baseline vitamin D status, lifestyle, and risk factors.

In Hungary, according to the updated 2022 “Hungarian Consensus Recommendation on the Role of Vitamin D in Disease Prevention and Treatment,” recommended vitamin D intake varies by age group. The goal is to maintain serum levels around or above 30 ng/mL, which may contribute long-term to colorectal cancer prevention, treatment, and reduction of recurrence risk.

Additionally, some recent publications highlight vitamin D3 supplementation’s potential benefits in anti-aging and general health maintenance: https://www.independent.co.uk/news/science/vitamin-d3-daily-anti-ageing-b2757496.html 

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Assessing Your House or Business for Mold...Is There a Right Way?: An Interview with James Weber

Having your home or business properly assessed for mold is key in the process that leads to successful remediation, detoxification and recovery from CIRS (Chronic Inflammatory Response Syndrome)...

Kirk Hamilton PAC, Jul 22, 2025

Watch Interview Here
Kirk hamilton pa-c interviews james weber

Specializing in Medically Important Remediation since 2014
James Weber
JW Environmental Remediation Services
11440 Sunrise Gold Cir Suite 24
Rancho Cordova, CA 95742
916-540-8595 / www.jwenviro.com
james@jwenviro.com

Background…
James Weber started in the family carpet cleaning business, which led him to having to deal with a lot of water damaged carpets that eventually led him to remediation of the water damaged or moldy areas. After doing remediation he found that he might get called back because the initial assessment was faulty and other areas of the residence were found to be moldy. This happened frequently enough that led him to start doing the initial assessment himself so as not to waste time and come back and treat more undiscovered mold. Therefore he became involved in not only the remediation or fixing of the mold problem but also the discovery of where “all” of the mold was. He doesn’t do the follow-up testing after remediation to “clear” the residence/building from mold. That is done by a 3rd party.

Medically Important Assessment and Medically Important Remediation…
He uses two terms which are unique - Medically Important Assessment and Medically Important Remediation. Both phrases go beyond just fixing the problem but to do it in a way that the reduces exposure and subsequent medical detoxification which will allow the patient to get well from the conglomeration of systems of what is called “Chronic Inflammatory Response Syndrome (CIRSs).” I encourage you to look at the “Resources for Patients” and the “Resources for Physicians” at SurvivingMold.com. Also I would look at the “Biotoxin Pathway (page 6 diagram)” which gets “triggered” in genetically mold sensitive patients which can result in a wide variety of multiple debilitating symptoms from different organ systems.

How to Test and Which Tests…
The question of if the client should to do “mold” testing is debatable. From listening to James my guess is he would like people to just call him first and tell him about their current situation. It might be cheaper overall for the client do testing after that discussion. The average cost may be around $1500 but that also depends on the size of the house and it’s location which are important factors. The triad of tests that I do (panel #8 $630-675 from Envirobiomics) include the ERMI test for mold, actinomyces and endotoxins is reasonable if you are trying to convince someone there is an issue in their house of toxic compounds that may be making one sick. There are graded scores on each test that suggest the severity of the results. Getting a good amount of dust sample from different areas in the house is important. Air testing and mold plates are problematic and can result in totally missing a moldy situation used by themselves.

Endotoxins can be important as these are organisms that create toxic gases around plumbing.

It is important for an independent third party to test the house right after the remediation is done. James feels there would be a conflict of interest if his company tested for mold right after remediation. The home or residence should be tested 4-6 weeks after the remediation as well.

A big “red flag” for a remediation company is if they use chemicals. James feels strongly the use of chemicals is not necessary or healthful for efficient Medical Important Remediation.

JW Environmental Remediation Services (916) 540-8595 james@jwenviro.com services the Northern California area and sometimes will go out of state.

Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
krhammer@surewest.net
www.StayingHealthyToday.com
www.HealthyLivingforBusypeople.com
www.KwikerMedical.com

Treating the Gut May Be One Answer for Post-Spike Syndrome (PSS) or Covid Long Haul Reports Brazilian Medical Group

Treating gut dysbiosis, reducing inflammation, and a hyperimmune response may resolve symptoms of extreme fatigue, brain fog, neuropathies, and reactivation of prior illnesses...5 case successes... (Watch YouTube Summary of this Research by Kirk Hamilton PA-C)

POST SPIKE SYNDROME (PSS)- DYSBIOSIS - BIFIDOBACTERIA -IVERMECTIN - NATTOKINASE - Post spike syndrome (PSS): Simple solution leading to resolving results, five cases report. ScienceDirect, IDCases, Volume 41, 2025, e02278. Zeballos RS et al.
Kirk’s Commentary: In this article 5 cases of dramatic resolution of systemic diseases are reviewed of females 44-70 years of age, two had both the Covid vaccination and cases of Covid; one had the vaccine and no Covid infection; and two had the Covid infections and no vaccine. The five cases had combined diagnosis of interstitial granulomatous dermatitis, polymyalgia rheumatica, peripheral polyneuropathy, drug-refractory epilepsy and trigeminal neuralgia.

*** HIGHLY RECOMMENDED LISTENING TO DR. PETER MCCULLOUGH INTERVIEWING Dr Roberto Zeballos who is the lead author of the above article from Brazil on the above paper reviewed on the McCullough Report July 14, 2025.

TREATMENT:
1) Four of 5 had 5 days of Cipro 500 mg daily first. The one who didn’t get Cipro because prior to the study period was placed on antibiotics but didn’t tolerate Augmentin but did take moxifloxacin HCL 400 mg for 14 days.
2a) Following the antibiotics was Nattokinase 100 mg twice daily was given for 90 days;
2b) Ivermectin 3 times per week for at least 8 weeks at 6 mg/30 kg (or 6 mg/66 lb; ex. ~130 lb women would take approximately ~ 12 mg daily of Ivermectin);
2c) Bifidobacteria probiotic providing 335 mg twice daily for 90 days (bifidobacter is known to be diminished in Covid patients).
Dr. Zeballo does the above treatment 4-6 weeks. Then he refers his patients to his nutritionist.
3a) Dr. Roberto Zeballos’s Nutritionist
Phase 1 - Diet: 3 days of raw foods - vegetables and fruit, berries, smoothies. eliminates animal protein/just fruit and vegetables.
Phase 2 - Diet next 5 days to 8 weeks a little bit of “protein”, vegetables, raw foods, smoothies, teas.
His nutritionist for 14 days no alcohol, gluten (wheat), dairy, sugar and processed carbohydrate.
3b) Dr. Zeballos recommends vitamin C regularly increases bifidobacteria and vitamin D sometimes. He doesn’t give very many vitamins. He is concerned about gastritis.
3c) Dr. Zeballo’s nutritionist recommends more supplements - beta-glucan, magnesium, selenium, psyllium fiber, bifidobacteria, enzymes, bioflavonoids, macha tea, green tea.
4) Exercise regularly
5) Meditation
6) Dr. Zeballo personally eats for “his body” 5 days a week and 2 days a week he eats for his heart. Small about of alcohol. Takes care of “soul” 2 days per week. Meditates in the sun and exercises.

During the pandemic Dr. Zeballos’s medical group treated more than 11,000 patients. Since January, 2023 they observed a “…surge in Post-Spike Syndrome (PSS) case. The number of cases has continued to rise, and we are currently seeing 3-4 new cases per day.” They have treated over 400 PSS patients in this manner with excellent results.

Conclusion: This is exciting because somehow the gut microbiota is altered by a Covid infection and/or Covid vaccine (or vice versa), with the implication that the spike protein from either is involved in triggering some type of vasculitis, inflammation or hyperimmune response possible through a leaky gut. The antibiotics may wipe out abnormal gut flora and the reinoculation of the bowel with bifidobacteria helps heal the gut and reduce inflammation. The nattokinase may help break down the spike protein, inhibiting clotting and/or vasculitis to some degree, while Ivermectin applies an anti-iflammatory or antiviral effect. Collectively they heal the gut and reinoculate it, reduce the spike protein, inflammation and immune challenge calming down the external illnesses described. You take these above case studies/article in conjunction last week’s interview with pancreatic cancer specialist from Japan, Makoto Abrue, MD, PhD and his paper Repeated COVID-19 Vaccination as a Poor Prognostic Factor in Pancreatic Cancer: A Retrospective, Single-Center Cohort Study and you can see the concern for the continued promotion of the Covid vaccine which delivers an altered spike protein that can “live” in the body for an unknown period of time and cause metabolic dysfunction resulting in other systemic diseases and symptoms. In this Brazilian research as in so many illnesses a healthy gut flora and barrier may help cure or minimize the expression of the disease.

*** HIGHLY RECOMMENDED LISTENING TO DR. PETER MCCULLOUGH INTERVIEWING Dr Roberto Zeballos the lead author of the above article from Brazil on this landmark paper on the McCullough Report July 14, 2025.
References:
Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity.
Cardiac findings in a phase II double-blind randomized placebo-controlled trial of combination therapy (HAZDPac) to treat COVID-19 patients.
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19).

For Appointments for the treatment of Covid, Covid Long Haul or Post Spike Syndrome, or Post Covid Vaccine problems contact Health Associates Medical Group 916-489-4400 and make an appointment with Kirk Hamilton PA-C.

For the rest of this post for links to "Current Research in Nutrition, Prevention and Integrative Medicine; Cancer and Covid Syndrome News" Click on THIS LINK to Kirk Hamilton’s “Staying Healthy Today” Substack. 

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Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
krhammer@surewest.net
www.StayingHealthyToday.com
www.HealthyLivingforBusypeople.com
www.KwikerMedical.com

Magnesium IV and Orally for Migraine Headaches, Headaches, and Pain Syndromes An Interview with Neurologist and Pain Specialist Alexander Mauskop, MD

Migraines, Headaches and Pain…The Beneficial Effects of IV and Oral Magnesium. A Neurologist’s 30 years of Clinical Experience.

“…1 gram of MSo4 given in 10 cc normal saline by IV push over 5-10 minutes may have a better clinical effect than diluting the magnesium and giving it slower in an IV drip…”

“Clinical Uses of Magnesium Intravenously and Orally in the Treatment of
Migraine Headaches, Headaches and Pain”
an Interview with Neurologist and Pain Specialist Alexander Mauskop, MD

Alexander Mauskop, M.D.
New York Headache Center
30 East 76th Street
New York, NY 10021 USA
(212) 794-3550 / (212) 794-0591 (FAX)
drmauskop@nyheadache.com
www.nyheadache.com

The Science Behind Magnesium and Headaches (video); and The End of Migraines: 150 Ways to Stop Your Pain (book); Migraine Headaches and Magnesium, 1996 Expert Interview with Kirk Hamilton PA-C (click on link – control F – search “Mauskop” to find 1996 interview)

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“Clinical Pearls” by Kirk Hamilton PA-C from neurologist Dr. Alexander Mauskop’s “Staying Healthy Today Interview”…

• Dr. Mauskop went to medical school in Ukraine right out of high school into a 6 year program. He did his four years of neurology residency in the United States at State University of New York (SUNY, 1979) and two years of pain fellowship at Sloan Kettering. He is a board certified neurologist and pain specialist. He has been treating headaches and pain syndromes for more than 30 years.

• Dr. Burton Altura (professor of physiology) at State University of New York exposed him in the early 1990s to the concept of using magnesium in the treatment of migraine headaches and the importance of ionizable magnesium as the most accurate measurement of magnesium (98% of magnesium is intracellular). 50% of patients during an acute migraine attack had lowered levels of ionized magnesium. 1) 2) 3) 4)

• The ones that responded to the IV magnesium and had headache symptoms reduced were magnesium deficient/insufficient. (RBC magnesium <5 mg/dl)

• Those who respond to intravenous magnesium are generally deficient. Magnesium therapy generally doesn’t work for migraines if the patient is adequate in magnesium (RBC 5-6.4 mg/dl).

• Magnesium is routinely given IV (MgSo4 – easily available, cost effective, and has been used in pre-eclampsia in much higher doses 5-6 gms so it is safe) 1-2 gm in 10 mls of normal saline over 5-10 minutes.

• Giving it over 5-10 minutes IV push versus a slower drip diluted in more fluid appears clinically to have a better effect (tapering speed to patient flush, warmth, sleepiness, light headedness, etc. if administered too fast). The possible explanation is a higher tissue level with the IV push driving magnesium into the cell versus during a slower IV drip the magnesium may be excreted through the urine. Always administer to patient laying down.

• People who are really deficient feel euphoric sometimes and they feel warm but comfortably so.

• This 1 gram IV push (in some patients 2 grams) can be done monthly prophylactically or for an acute headache. Always give IV magnesium with the patient lying down.

• Oral magnesium can be used prophylatically and the best assessment for the average clinician is RBC magnesium, not serum. Also the general range of RBC magnesium is 4.0-6.4 mg/dl. You want to get to 5 or above to reduce the likelihood of insufficiency.

• He usually gives IV magnesium either in subjects with an acute headache and those that come in monthly IV for their shot.

• There are many types of oral magnesium products (i.e glycinates, citrates, gluconates, taurates, oxides, aspartates, chelates, threonate, chloride, etc.). Whatever a patient chooses for oral intake should be followed by a RBC magnesium test trying to get a level greater than 5. The only real side effect from oral intake is diarrhea. Oral intake is reasonable between 350-450 mg/d with no GI upset or loose stools.

• Take the magnesium at night can help them sleep.

• The best time for a monthly injection is premenstrual for women. The magnesium can prevent a headache and reduce menstrual cramps.

• Other pain syndromes that may benefit from IV magnesium are the pain of fibromyalgia, IBS, low back pain, shingles, neck pain…conditions that have low or low normal RBC magnesium of less than 5 mg/dl (optimal 5.0-6.4).

• Magnesium is a predominantly an intracellular ion and acts as a natural “calcium channel blocker”. It effects over 300 enzyme systems in the body. It may work in migraine by 1) dilation and relaxation of blood vessels inhibiting or reversing blood vessel spasm 2) The magnesium ion “sits” inside the NMDA receptor blocking calcium’s entry and therefore blocking the transmission of pain. 3) Magnesium has an anti-inflammatory effect.

• Magnesium deficiency may play a role in migraines by promoting cortical spreading depression, alteration of neurotransmitter release and the hyperaggregation of platelets.

• Other nutrients that may benefit migraines: Vitamin B12 (> 500 pg/ml, closer to a 1000 may be more optimal); CoQ10 with levels > 1 mg/L, vitamin D > 50 ng/ml; vitamin B2; omega fatty acids (omega check ~ 5); ginger; alpha lipoic acid.

• Food intolerance can play a role. He states the most common cause is sugar. When people consume sugar they may have a low blood sugar response and subsequent headache. Sometimes he will use metformin. Other commonly mentioned foods are: caffeine too much and withdrawal; sweets, chocolate, foods that are smoked, pickled, cured, have preservatives, sulfites, nitrates; cheese, dairy products, gluten. Any food can if particular to that individual.

• Dr. Mauskop is a licensed acupuncturist and recommends 3-4 treatments to see if the patient will respond (works for 60% of people). People who really “enjoy” the initial treatment are generally the best responders.

• Biofeedback, electrical stimulation may be of benefit.

• Meditation is recommended.

• There are so many options for headache sufferers. There is always one more thing to try. Check out Dr. Alexander Mauskop’s book The End of Migraines: 150 Ways to Stop Your Pain.

Alexander Mauskop’s MD Partial Publication List:

Serum ionized magnesium levels and serum ionized calcium/ionized magnesium ratios in women with menstrual migraine
Complementary and alternative approaches to the treatment of tension-type headache
Role of magnesium in the pathogenesis and treatment of migraine
Foods and supplements in the management of migraine headaches
Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
Magnesium in headache
Alternative headache treatments: nutraceuticals, behavioral and physical treatments
Why all migraine patients should be treated with magnesium
Nonmedication, alternative, and complementary treatments for migraine
Complementary and alternative approaches to the treatment of tension-type headache
Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society
Nutraceuticals in Acute and Prophylactic Treatment of Migraine
Stem Cells in the Treatment of Refractory Chronic Migraines
Intravenous Magnesium Sulfate to Treat Acute Headaches in the Emergency Department: A Systematic Review – A Comment
One-Year Consistent Safety, Utilization, and Efficacy Assessment of Remote Electrical Neuromodulation (REN) for Migraine Treatment

For Appointments for the treatment of headaches and other pain syndromes utilizing diet, nutritional supplements, shockwave therapy, exercise contact Health Associates Medical Group 916-489-4400 and make an appointment with Kirk Hamilton PA-C.

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• Dr. Joe Dispenza’s Website

• Practice, Persistence and Patience – My Favorite. The first story of transformation that “jumped out” at me before my cancer and then the first one “sent” to me after my cancer diagnosis. A physician cures herself of a rare, life threatening sarcoma after chemo, radiation and alternative therapies had been tried.

• ”Source” the Documentary – The Science behind the practice. Highly recommended.

• Proof – Stories of Transformation (listen to a few stories of transformation from serious health problems)

• Stories o” f Transformation – YouTube Channel

• Research: The Science Behind Mind/Body Healing and Meditation

• Dr. Joe Dispenza’s Book: Becoming Supernatural

Falun Dafa – Truthfulness, Compassion and Forbearance

Brief Introduction to Falun Dafa
Books & Recent Writings of Mr. Li Hongzhi
Video & Audio Materials
Take an Online Class

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Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
krhammer@surewest.net
www.StayingHealthyToday.com
www.HealthyLivingforBusypeople.com
www.KwikerMedical.com

Repeated Covid Vaccinations Result in Poorer Pancreatic Cancer Outcomes...An Interview with Makoto Abue, MD, Miyagi Cancer Center, Miyagi, Japan...

(video summary)

"..despite no major changes in our treatment system, the prognosis began to deteriorate from 2021 and worsened significantly after 2022. This period coincided exactly with the start of vaccination.."

Pancreatic Cancer Prognosis Worsened After Repeated Covid-19 Vaccination

Makoto Abue, MD
Department of Gastroenterology
Miyagi Cancer Center Nodayama 47-1, Medeshima-Shiote, Natori
Miyagi, Japan, 981-1293 (7/2025)
+81-22-384-3151 tel / +81-22-381-1174 (FAX)
abue-ma742@miyagi-pho.jp

“Repeated COVID-19 Vaccination as a Poor Prognostic Factor in Pancreatic Cancer: A Retrospective, Single-Center Cohort Study. Cancers (Basel). 2025 Jun 16;17(12):2006. PDF  (Author Updated 7-10-25)

Kirk Hamilton:            Can you please share with me your educational background and current position?

Makoto Abue:              First, let me introduce myself. After graduating from Jichi Medical University in 2000, I worked in community medicine for seven years following two years of initial training. Since then, I have worked at the Miyagi Cancer Center for approximately 16 years. During this time, I conducted research on microRNA (miRNA) and obtained a Ph.D... I specialize in gastroenterology and oversee the biliary tract and pancreatic areas. I am currently the head of the gastroenterology department. The academic societies I belong to include the Japanese Society of Gastroenterology, Japan Gastroenterological Endoscopy Society, Japan Pancreas Society, and Japan Biliary Association. I mainly perform endoscopic examinations and treatments of the biliary tract and pancreas, as well as chemotherapy. My lifelong goal is to improve pancreatic cancer prognosis. To that end, I am interested in finding tests and treatments that lead to better prognoses. Conversely, I am interested in avoiding or overcoming those that may lead to poor prognoses. My intention is to provide pancreatic cancer patients with as many benefits as possible.

KH:       What got you interested in studying the role of repeated Covid vaccinations and pancreatic cancer prognosis?

MA:      As shown in our paper, the prognosis of pancreatic cancer gradually improved until 2020 due to the developments in diagnosis and treatment. However, despite no major changes in our treatment system, the prognoses began to deteriorate from 2021 and worsened significantly after 2022. This period coincided exactly with the start of Covid vaccination, raising concerns that the booster vaccination was having a negative impact. Under these circumstances, I further questioned the situation where repeated vaccinations of three, four, five or six times in a short period of time were recommended. In Japan, there is a lack of sufficient verification of actual clinical data (real-world data) on the efficacy and safety of repeated vaccinations, including additional vaccinations. In particular, we believe that more research is needed on evidence related to additional vaccinations. We have been waiting for the government to conduct such verification, but, as there has been no progress, we have decided to investigate the effects of additional vaccinations at our facility.

KH:       What is the significance of IgG4 levels in cancer and pancreatic cancer patients specifically? What does the term “immune suppressor” with regards to IgG4 levels mean?

MA:      IgG4, one of the subclasses of IgG, has attracted attention due to its role in allergic reactions and autoimmune diseases. IgG4-related diseases are a group of diseases characterized by the infiltration of organs with IgG4-positive plasma cells and lymphocytes, accompanied by fibrosis. In the field of pancreatic diseases, these diseases are of interest due to the need to differentiate them from cancer through imaging, as well as their association with cancer. In healthy individuals, IgG4 accounts for only a few percent of all IgGs. The Fc region of IgG4 is characterized by its inability to activate complement C1q and its low binding affinity for Fcγ receptors. This property of IgG4 suppresses excessive Fcγ receptor-mediated immune responses. Furthermore, IgG4 is thought to exert anti-inflammatory effects by becoming a functional unit through Fab arm exchange. Production of IgG4 is induced by antigen stimulation and Th2-type cytokines, such as IL-4 and IL-13. It has also been reported that activation of IL-10-producing regulatory T cells in a Th2-dominant environment further promotes IgG4 production. Thus, high levels of IgG4 suggest that the organism may be shifting toward immunosuppression and anti-inflammation.

KH:  When you say “spike-specific” IgG4 levels I am assuming you are referring to the spike protein? Why only measure “spike-specific” IgG4 levels? Why not also measure the nucleocapsid IgG4 levels to the SARSCov2 virus?

MA:      In our paper, “spike-specific” means “spike protein-specific”. This study did not consider nucleocapsid proteins. These proteins are important for studying antibody dynamics, including the effects of infection, and they may further clarify the relationship between vaccines and the immune response. In this study, we examined the prognosis of pancreatic cancer patients who received repeated vaccinations. Our focus was on the impact of repeated vaccination rather than infection. Previous studies have reported that repeated mRNA vaccination increases spike protein-specific IgG4. The aim of this study was to validate this finding and determine whether there is a relationship between IgG4 and the poor prognosis of pancreatic cancer. Based on these results, spike-specific IgG4 alone was sufficient for evaluation, and nucleocapsid protein was not measured. However, nucleocapsid proteins may provide additional insight, and this study is a topic for future investigation.

KH:       Is the spike protein the “toxic,” “inflammatory” or “procarcinogenic” component of the Covid vaccination/booster?

MA:      The mRNA-LNP platform produces spike proteins and stimulates the production of antibodies. Our study showed that individuals who received three or more doses of the mRNA vaccine had elevated IgG4 levels. The shift to IgG4 is notable for its immunosuppressive and anti-inflammatory properties, and it is an active area of research. Some hypothesize that this response may be due to, or contribute to, excessive or prolonged immune activation. Conversely, others suggest that it is a mechanism of immune tolerance to repeated exposure to the antigen. The precise clinical significance of IgG4 elevation after multiple vaccinations and the role of spike proteins in the potential inflammatory process are topics for future research. Mentioning the "toxicity" and "carcinogenicity" of spike proteins in this study may be difficult. Nevertheless, concerns have been reported about the organ-damaging properties of the spike protein, including its effects on the heart, blood vessels, nerves, and ovaries. Regarding carcinogenicity, some experts are concerned about SV40 contamination, estrogen receptor effects, and effects on tumor suppressor genes. We believe these concerns require further validation.

KH:       Can you tell us a little bit about your study and the basic results?

MA:      In our study, when we investigated prognosis in overall survival of pancreatic cancer, we found that those who received 3 or more COVID-19 vaccinations had significantly shorter survival. And when we investigated IgG4 among them, we found that IgG4 was elevated in patients who had received three or more vaccinations, again indicating a poor prognosis (IgG4 was particularly elevated in patients with short prognoses, such as those who died within 90 days). Additionally, regulatory T cells were also prominent in cancer cells of frequent vaccinators and those with high IgG4 levels. It was suggested that frequent vaccinations may lead to immune evasion of cancer, creating an environment conducive to cancer growth. We further investigated the relationship between spike-specific IgG4 and total IgG4. The results showed that spike-specific IgG4 increased markedly with increasing vaccination frequency. Spike-specific IgG4 was positively correlated with total IgG4, and those with elevated spike-specific IgG4 also tended to have higher total IgG4 levels. In other words, repeated mRNA vaccination over a short period of time tended to elevate IgG4, suggesting that the immune balance may have shifted toward suppression. However, this is a single-center, retrospective cohort study with a limited number of cases. Therefore, we believe that further large-scale validation and discussion are needed. We hope that our paper will serve as a starting point.

KH:       In your opinion should Covid boosters not be recommended in pancreatic cancer patients? How about cancer patients in general? Should they get Covid vaccinations, boosters or initial injections?

MA:      Based on the results of this study, I would personally be reluctant to recommend short-term, repeated vaccination for all solid tumors, including pancreatic cancer. Our findings may be applicable to many cancer patients. However, our results are based on a single hypothesis from a single-center, retrospective cohort study and are open to further discussion. Public health agencies continue to make recommendations for cancer patients, and we refer readers to these agencies for comprehensive reviews. To date, the benefits have been considered to outweigh the risks. Nevertheless, breakthrough infections following vaccination are now common, and the virus has been attenuated. The number of peer-reviewed papers on various adverse effects is also increasing. For better public health policy, we believe that the efficacy and safety of vaccines need to be reexamined and debated.

KH:       There has been a term called “turbo cancers” in public social media circles associated with the Covid vaccines. Meaning more cancers occurring in younger patients, with faster progression, or quicker recurrence of cancers and more rapid progression to death in patients with prior cancers. Might this above observation, the elevated IgG4 spike specific antibody levels in cancer patients with more rapid progression, be a cause of these “turbo cancers” and a sound reason not to get further Covid immunizations?

MA:      Due to the risk of myocarditis and the low severity of the infection, caution should be exercised when considering the vaccination of young patients. Furthermore, the results of this study suggest that repeated vaccination in a short period of time may not benefit cancer patients. Whether these results are sufficient reason to avoid vaccination requires extensive validation and debate among public health authorities, academics, and the general public.

KH:       Are you aware of any way to lower the “spike-specific IgG4” levels? i.e Nattokinase, bromelain, curcumin, NAC, etc.) 1) 2) 3) 4) (See Base Spike Protein Detoxification algorithm halfway down the page)

MA:      I don't know of any way to reliably lower it. However, the half-life of IgG4 is usually about three weeks. I believe that it will settle down if there are no repeated vaccinations or infections within a short period of time. Once chronic antigenic stimulation ends and the body clears spiked proteins, I believe the immune balance will gradually normalize. There may be individual differences, depending on one's ability to process the spike protein. Of course, using the method described in the link may be a good idea.

KH:       Do you ever measure quantitative IgG spike protein antibodies in those cancer patients who have been vaccinated and see if higher levels of these spike protein antibodies is correlated to recurrence?

MA:      Our institution has not studied the quantification of spike-specific IgG antibodies and cancer recurrence.  Due to our current clinical workload and limited research and human resources, it is difficult to continue and develop research independently at our institution. (However, if the idea of a collaborative study with another facility emerges, we may consider the study).

KH:       Any closing thoughts you may have on this very interesting and timely topic?

MA:      Thank you for this interview today. I appreciate your interest in my research. I hope it will give as many people as possible an opportunity to think about vaccination and their own immunity.

KH:       Thank you Dr. Abue for your timely, detailed, credible and critically important work which may save lives and much human suffering.

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• Dr. Joe Dispenza’s Website

• Practice, Persistence and Patience - My Favorite. The first story of transformation that “jumped out” at me before my cancer and then the first one “sent” to me after my cancer diagnosis. A physician cures herself of a rare, life threatening sarcoma after chemo, radiation and alternative therapies had been tried.

• ”Source” the Documentary - The Science behind the practice. Highly recommended.

• Proof - Stories of Transformation (listen to a few stories of transformation from serious health problems)

• Stories o” f Transformation - YouTube Channel

• Research: The Science Behind Mind/Body Healing and Meditation

• Dr. Joe Dispenza’s Book: Becoming Supernatural

Falun Dafa – Truthfulness, Compassion and Forbearance

Brief Introduction to Falun Dafa
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Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
krhammer@surewest.net
www.StayingHealthyToday.com
www.HealthyLivingforBusypeople.com
www.KwikerMedical.com

Staying Healthy Today Research for July 3, 2025

Nutrition, Prevention and Integrative Medicine…

AGING – CREATINE- MUSCLE – 3 Reasons Creatine Is The Ultimate Longevity Supplement. By Molly Knudsen, M.S., RDN, MindBodyGreen, June 19, 2025.
1) It helps you build muscle (during a time when muscle loss is common). The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis.
2) It supports bone health. Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women.
3) It supports sharper thinking & a better memory. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials.

AGING – OMEGA-3 FATTY ACIDS – VITAMIN D – Recent Study Shows Omega-3s & Vitamin D Slow Biological Aging. By Molly Knudsen, M.S., RDN MindBodyGreen, June 18, 2025.
1) Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.

ALZHEIMER’S – COGNITIVE DECLINE – SLEEP – Are You Getting Enough Sleep? Experts Say It’s Essential If You Want To Prevent Neurological Conditions. By Sarah Regan, June 13, 2025, MindBodyGreen.
1) Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.

ALZHEIMER’S DISEASE – EXERCISE – Role of Exercise in Prevention of Alzheimer’s Disease. Studies Find Considerable, Consistent Benefit, Peter A. McCullough, MD, MPH, Jun 16, 2025.
1) Physical exercise in the prevention and treatment of Alzheimer’s disease.
2) Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence.
3) Physical exercise, cognition, and brain health in aging.

BLOOD PRESSURE – BEET JUICE – Blood Pressure Reduction with Beet Root. Daily Juice or Supplements Worth a Shot, Peter A. McCullough, MD, MPH, Jun 15, 2025.
1) The Nitrate-Independent Blood Pressure–Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis.

BRAIN FUNCTION – OLIVE OIL – How Olive Oil Benefits Brain Function. This special oil may help combat neurodegenerative disease. By Zena le Roux, EPOCH Times, 6/23/2025.
1) Olive Oil Phenolic Compounds’ Activity against Age-Associated Cognitive Decline: Clinical and Experimental Evidence.
2) Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death.

BURNS – CHOLORINE DIOXIDE – CHLORINE DIOXIDE to treat BURNS – “Infection prevention and tissue repair based on a chlorine dioxide solution” – rare 2022 paper by Mexican Orthopedic Surgeon Manuel Aparicio-Alonso, Dr. William Makis MD, Jun 21, 2025.

CHERRIES – ANTIOXIDANT – Research Shows Antioxidant-Rich Tart Cherries Support Recovery, Performance & Sleep*, Registered Dietitian Nutritionist, By Molly Knudsen, M.S., RDN, MindBodyGreen, March 6, 2025.
1) Tart Cherry Supplementation and Recovery From Strenuous Exercise: A Systematic Review and Meta-Analysis.
2) Effect of Tart Cherry Concentrate on Endurance Exercise Performance: A Meta-analysis.
3) Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males.
4) Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms.
5) Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity.
6) Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults.

COGNITION – NUTRIENTS – 7 Anti-Alzheimer’s Nutrients and How to Take Them—A Brain Surgeon’s Guide. (curcumin, quercetin, tea catechins, omega-3 fatty acids, Vitamin E, luteolin, magnesium)

DRUG INDUSTRY – BIG PHARMA – New ACIP Panel, Senators Push to Eliminate Direct-to-Consumer Drug Advertising. Will These Changes Restore Public Trust? Break BIG PHARMA Control over Media?, Peter A. McCullough, MD, MPH, Jun 17, 2025.

EYE EXERCISES – CATARACT – GLAUCOMA – 20-Minute Eye Care Routine to Protect Against Glaucoma and Cataracts. A set of eight effective eye exercises, designed to support a range of eye issues you can do at home. By Kuo-Pin Wu, EPOCH Times, 6/19/2025.

NEUROLOGIC DISEASE – MUSHROOM – LION’S MAIN – Lion’s Mane Mushroom May Help Reverse Neurodegenerative Disease and Iatrogenic Brain Damage. With over 43% of the global population affected by neurological disorders, mounting clinical and experimental evidence supports Lion’s Mane mushroom as a powerful neuroregenerative compound. Nicolas Hulscher, MPH, Jun 17, 2025.
1) Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021.
2) Catastrophic Neurological and Psychiatric Damage from COVID-19 ‘Vaccines’.Increased risks of ischemic stroke, hemorrhagic stroke, transient ischemic attack, myelitis, myasthenia gravis, Alzheimer’s disease, cognitive impairment, depression, anxiety, and sleep disorders. Nicolas Hulscher, MPH, Jan 05, 2025.
3) Study Identifies 86 Serious Neuropsychiatric Safety Signals Linked to COVID-19 Vaccination. CDC/FDA safety thresholds breached for 86 adverse events including dementia, schizophrenia, suicidal and homicidal thoughts, stroke, psychosis, depression, cognitive impairment, delusions, and more. Nicolas Hulscher, MPH, Apr 14, 2025.
4) Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?

PELVIC FLOOR EXERCISES – 8 Steps To Optimizing Your Pelvic Floor Health At Every Age, By Jason Wachob, MindBodyGreen, June 15, 2025.

PELVIC FLOOR WEAKNESS – Signs Of A Weak Pelvic Floor & How To Strengthen Yours, A Urologist Explains. By Megan Falk, MindBodyGreen, June 21, 2025,

PILOT INCAPACITATION – May 23, 2025 United Airlines Flight UA-194 (SFO-MUC) from San Francisco, CA to Munich Germany with 286 people on board – first officer incapacitated. Dr. William Makis MD, Jun 19, 2025.

PILOT INCAPACITATION – United Airlines Flight UA-71 (AMS-EWR) from Amsterdam to Newark, NJ, USA on April 15, 2025 – pilot had a “heart ache”. Dr. William Makis MD, Jun 19, 2025.

PILOT INCAPACITATION – March 24, 2025 Iberia Airlines Flight IB1679 (MAD-PMI) Madrid to Palma flight crew had medical emergency. Dr. William Makis MD, Jun 21, 2025

PREGNANCY – NAUSEA – MITOCHONDRIA – Nausea and Vomiting of Pregnancy Is Mitochondrial Dysfunction. The fascinating intersection between pregnancy and mitochondrial dysfunction and what to do about it. Chris Masterjohn, PhD, Jun 15, 2025.

TOXINS – MICROPLASTICS – HUMAN BLOOD – Blood Filtration May Remove Microplastics from the Human Body. New study offers first evidence that therapeutic apheresis can extract microplastics from human blood. Nicolas Hulscher, MPH, Jun 20, 2025

VACCINES – ALUMINUM – ASTHMA – AUTISM – SIDS – Five Studies Link Aluminum Vaccine Adjuvants to Asthma, Autism, and SIDS. Mass aluminum-based hyper-vaccination of children is pouring kerosene on the fire of chronic disease. Nicolas Hulscher, MPH, Jun 19, 2025.
1) Reviewing the association between aluminum adjuvants in the vaccines and autism spectrum disorder.
2) Aluminium in brain tissue in autism.
3) Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
4) Vaccines May Trigger Sudden Infant Death Syndrome via Brainstem Failure. New study finds that immature infant livers may fail to clear toxic vaccine ingredients—triggering inflammation and brainstem dysfunction that can lead to sudden death during sleep. Nicolas Hulscher, MPH, Jun 03, 2025.
5) Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months.

Vitamin C and Your Hormones, Especially Your Adrenal Glands

Adrenal Glands, Vitamin C and Health

The adrenal glands have a very high concentration of vitamin C, among the highest in the body. Vitamin C is crucial for the synthesis of adrenal hormones, especially those involved in the stress response. The adrenal glands are very important in regulating blood sugar, blood pressure, keeping inflammation down and helps detoxify just about anything from poisonings, insect bites, allergic reaction, etc..

The “God Father” of vitamin C in large dosage used clinically is former chest specialist Frederick Klenner, MD which Dr. Lendon Smith excellently collated his works and writings in his small, easily read book, Clinical Guide to the Use of Vitamin C. The Clinical Experiences of Frederick R. Klenner, M.D. abbreviated, summarized and annotated by Lendon H. Smith, M.D..
Kirk’s Comment: I personally don’t get into the different forms of vitamin C to say which is best. I frequently take a sodium ascorbate / ascorbic acid mix (1/4 tsp = 1000 mg) and just flick in on my tongue. Do a little “pucker” and I can feel it almost right away. A little uplift in energy, reduced reaction to a food or environment.

Cofactor for Hormone Production:
Vitamin C acts as a cofactor for enzymes involved in the production of adrenal hormones like cortisol and adrenaline.

Antioxidant Protection:
The adrenal glands are vulnerable to oxidative stress during hormone production. Vitamin C, as a potent antioxidant, helps protect them from damage.

Stress Response:
During stress, the adrenal glands release more cortisol and vitamin C, and some studies suggest that adrenal vitamin C levels may decrease during periods of stress due to increased utilization.

Adrenal Fatigue:
Vitamin C can be helpful in managing adrenal fatigue by supporting adrenal hormone production and protecting against oxidative stress.

HORMONES – Let’s Discuss: The Oft-Overlooked Nutrient That Helps Balance Mood & Hormones. By Hannah Frye, Beauty & Health Editor. MindBodyGreen, June 15, 2025.
1) Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla.
2) Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006.
3) Vitamin C improves endothelial function in healthy estrogen-deficient postmenopausal women.
4) Ascorbic acid is associated with favourable hormonal profiles among infertile males.
5) Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy.
6) Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress.
7) Vitamin C: an essential “stress hormone” during sepsis.
8) Ascorbic acid is associated with favourable hormonal profiles among infertile males.
9) Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy.

Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
https://stayinghealthytoday.substack.com/ 
krhammer@surewest.net
www.StayingHealthyToday.com
www.HealthyLivingforBusypeople.com
www.KwikerMedical.com

A Integrative Cardiologist's View on the Importance of the Endothelial Function and Heart Disease

WATCH INTERVIEW HERE OR HERE

“Clinical Pearls” from Dr. Van on the Importance of Optimizing The Endothelium

• PATIENT INSPIRATION TO CHANGE FROM DRUGS TO NUTRIENTS: Patients inspired him by showing improvement in their health by taking supplements such as higher doses of vitamins C and D (5000 IU/d) and a broad spectrum high potency multivitamin/mineral (helped a patient dramatically with a neurologic condition) . This inspired him to look beyond drugs. Drugs give one possible benefit with the possibilityof many side effects. Patients also inspired him to look at prevention.

• SELF -EDUCATED - Through patients, the internet and physicians such as neurosurgeon Russell Blaylock and hypertension specialist, internist at Vanderbilt University, Mark Houston, MD.

• ENDOTHELIUM - The endothelium is the pristine inner layer of the artery lined with a slimy hair-like substance called the glycocalyx that protects us from the atherosclerotic process. The endothelium is the critical inner boundary of the 3 layers of each artery. It is a single layer thick. The endothelium keeps blood flowing smoothly and releases nitric oxide to help dilate the arteries. It is a barrier that protects the artery. The endothelium is said to have a surface area as large as a tennis court. On the inner lining of the endothelium is the glycocalyx discovered 30 years ago which is very fragile, “slimmy” and can be damaged easily, like the endothelium. Things that can damage either are a sedentary lifestyle, smoking, excess sugar consumption, uncontrolled hypertension and seed oils.

• ATHEROSCLEROSIS: Oxidative stress from mitochondrial energy production can cause endothelial damage leading to atherosclerosis from inflammatory cytokines which attract white blood cells to attach to the endothelium. White blood cells can get through the endothelium into the middle layer and create plaque. Monocytes, a type of white blood cell, can get through the endothelium and become a macrophage which gobbles up damaged LDL cholesterol creating a foam cell causing inflammation, plaque and atherosclerosis. When LDL cholesterol becomes oxidized, it can become smaller and denser, forming small, dense LDL (sdLDL). This transformation is associated with increased atherosclerosis risk. Oxidized LDL (oxLDL) is more easily trapped in the artery walls, promoting inflammation and the formation of foam cells, which contribute to plaque buildup.

• MEASURING ENDOTHELIAL FUNCTION - Vascular elasticity testing measures large arteries (C1) and small arteries (C2) leading to the capillaries and end organs. C2 arteries are much more dependent on good endothelial function and health. The C2 arteries effect oxygen being delivered to the end organ via the capillaries. So having normal C2 function is more important for overall vascular risk than a C1 measurement and is more correlated with overall vascular health.

• LIPID PROFILE & CARDIOVASCULAR RISK: A Triglyceride/HDL ratio < 2.0 is optimal to maintain a healthy LDL cholesterol. The closer to one the better. When LDL cholesterol is not oxidized, large and “fluffy” is not a cardiovascular risk factor. This T/HDL ratio can be seen on any basic lipid profile by just dividing the total triglycerides by the HDL number.

• DIET: Mediterranean Diet with good fats, organic vegetables, fruits, nuts, low glycemic whole carbohydrates, free ranged meats, fish - olive oil, avocado and coconut oils are optimal. Avoid pastas, processed carbohydrates, high fructose corn syrup, sugars, sweets and seed oils.

• CHOLESTEROL: Dr. Van does not believe cholesterol is bad for heart disease. Sugar is the real enemy and high glycemic carbohydrates.

• SUPPLEMENTS: Arterosil derived from sea algae (rhamnan sulfate a marine polysaccharide) provides nutrition to the endothelium and glycocalyx. It has been shown to remove plaque in the carotid arteries. He recommends products that make nitric oxide from the endothelium that dilate arteries (beet root derivatives), age garlic extract, omega 3 fatty acids, curcumin, green tea extract, vitamin C, magnesium, N-acetylcysteine, etc. Chelation therapy can be of benefit by helping to reduce heavy metal burden.

• EXERCISE: Exercise 150 minutes per week of aerobic exercise - walking, biking, jogging, etc. is recommended for a healthy endothelium. Strength training also helps improve vascular flow to muscles during growth and stress.

• BIG PHARMA - Big Pharma owns many aspects of medicine. Drugs are not the answer to improving vascular disease. If you help the endothelium you pretty much helps every organ in the body.To read all the additional information and topics on this substack please CLICK HERE:
  To subscribe to Kirk Hamilton PAC's Substack to receive information like this and more: CLICK HERE:

Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
https://stayinghealthytoday.substack.com/ 
krhammer@surewest.net
www.StayingHealthyToday.com
www.HealthyLivingforBusypeople.com
www.KwikerMedical.com

Food Causes Pain...Try the "BED" Diet for Two To Four Weeks!

Watch Kirk’s YouTube Video: Any food can cause pain. It can be 5% of your problem or 90% of your problem. Point being before or as you do any type of pain management treatment from chiropractic, to massage, or prolotherapy, stem cells or injection of joints with anything follow these five diet rules for 2-4 weeks. Eat NO DAIRY PRODUCTS, WHEAT CONTAINING FOODS (all junk carbs), NO EGGS and if you can do it NO ALCOHOL and cut your COFFEE way back or eliminate it. And EAT ONLY UNPROCESSED, WHOLE FOODS. Like you were at a farmers market. I have seen food elimination bring 5% pain relief to 95%. Remember if you don't adjust your diet you are going to pay more money for extra treatments for whatever. Just try a Whole Food "BED" Diet (Basic Elimination Diet) minus alcohol and coffee if you can for a month. Just EAT OFF THIS FOOD LIST at this link. (PAGE 2 IS FOOD LIST TO EAT FROM - NOT ELIMINATE) If you would like to know more about the type of shock wave therapy I use and the devices read here. https://www.eswt.info/en/ and here https://www.emtt.info/en/ You can contact me at 916-489-4400 or at https://kwikermedical.com/

Be Well,

Kirk

Kirk Hamilton PA-C
Health Associates Medical Group
3301 Alta Arden, Suite 3
Sacramento, CA 95825
(916) 489-4400 (w)
krhammer@surewest.net
www.KwikerMedical.com
www.HealthyLivingforBusypeople.com
www.StayingHealthyToday.com